Ontology highlight
ABSTRACT:
SUBMITTER: Li HZ
PROVIDER: S-EPMC9575166 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Li Hao-Zheng HZ Shao Xiao-Xia XX Shou Li-Li LL Li Ning N Liu Ya-Li YL Xu Zeng-Guang ZG Guo Zhan-Yun ZY
ACS medicinal chemistry letters 20220929 10
The orexigenic peptide ghrelin exerts important functions in energy metabolism and has therapeutic potential to treat certain diseases. Native ghrelin carries an essential <i>O</i>-fatty acyl moiety; however, this post-translational modification is susceptible to hydrolysis by certain esterases in circulation, representing a major route of its in vivo inactivation. In the present study, we developed a novel approach to prepare various esterase-resistant ghrelin analogs via photoinduced thiol-ene ...[more]