Ontology highlight
ABSTRACT:
SUBMITTER: Maier BD
PROVIDER: S-EPMC9629604 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Maier Benjamin D BD Aguilera Luis U LU Sahle Sven S Mutz Pascal P Kalra Priyata P Dächert Christopher C Bartenschlager Ralf R Binder Marco M Kummer Ursula U
PLoS computational biology 20221021 10
Interferon (IFN) activates the transcription of several hundred of IFN stimulated genes (ISGs) that constitute a highly effective antiviral defense program. Cell-to-cell variability in the induction of ISGs is well documented, but its source and effects are not completely understood. The molecular mechanisms behind this heterogeneity have been related to randomness in molecular events taking place during the JAK-STAT signaling pathway. Here, we study the sources of variability in the induction o ...[more]