Ontology highlight
ABSTRACT:
SUBMITTER: Esteve PO
PROVIDER: S-EPMC9700808 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Estève Pierre-Olivier PO Sen Sagnik S Vishnu Udayakumar S US Ruse Cristian C Chin Hang Gyeong HG Pradhan Sriharsa S
Communications biology 20221125 1
In mammalian cells, SET8 mediated Histone H4 Lys 20 monomethylation (H4K20me1) has been implicated in regulating mitotic condensation, DNA replication, DNA damage response, and gene expression. Here we show SET8, the only known enzyme for H4K20me1 is post-translationally poly ADP-ribosylated by PARP1 on lysine residues. PARP1 interacts with SET8 in a cell cycle-dependent manner. Poly ADP-ribosylation on SET8 renders it catalytically compromised, and degradation via ubiquitylation pathway. Knockd ...[more]