Dataset Information

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

ABSTRACT:

Objective

To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism.

Design

In a single-arm intervention, 16 adults (mean age 59.9 yrs; BMI: 29.0 ± 4.3 kg/m²; 77% female) with radiographically diagnosed knee OA (Kellgren-Lawrence [KLG]: 2-4) and moderate to severe pain score (≥6) from the Western Ontario and McMasters Universities Index (WOMAC) enrolled in a 6-week, twice weekly, supervised HIIT cycle ergometry intervention. The primary outcome was feasibility; secondary outcomes included change in peak oxygen consumption (VO₂peak), WOMAC, and circulating biomarkers of metabolism.

Results

Feasibility was moderate; of the 21 participants screened by phone, 16 were enrolled; 13 completed pre- and post-testing. The average adherence rate (sessions completed/available) was >96%. VO₂peak was significantly improved (mean ± SD: 2.6 ± 3.0 mL/min/kg; 95% CI [0.70-4.56]). Significant improvements in WOMAC (mean ± SD: -8.7 ± 12.5; CI: [18.9 to -2.80]), pain [-5.15 to -1.01], and function [-12.9 to -0.98] resulted. There was a significant reduction in concentrations of amino acids: methionine, phenylalanine, and tyrosine (p < 0.02 for all), with trends towards lower concentrations of serine (p = 0.08; [-20.66-1.18]) and greater aspartate/asparagine (p = 0.06; [-1.99-65.73].). Post-training acylcarnitine concentrations were reduced with training.

Conclusions

In this cohort of overweight adults with symptomatic knee OA, 6-weeks of HIIT cycling showed excellent rates of retention and adherence with no adverse events, improved cardiorespiratory fitness and OA symptoms, in concert with metabolic alterations indicative of improved skeletal muscle energetics.

Trial registration number

clinicaltrials.gov: NCT03039452.

SUBMITTER: Smith-Ryan AE

PROVIDER: S-EPMC9718145 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Smith-Ryan Abbie E AE Blue Malia N M MNM Anderson Kara C KC Hirsch Katie R KR Allen Kelli D KD Huebner Janet L JL Muehlbauer Michael J MJ Ilkayeva Olga R OR Kraus Virginia Byers VB Kraus William E WE Golightly Yvonne M YM Huffman Kim M KM

Osteoarthritis and cartilage open 20200610 4

<h4>Objective</h4>To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism.<h4>Design</h4>In a single-arm intervention, 16 adults (mean age 59.9 yrs; BMI: 29.0 ± 4.3 kg/m<sup>2</sup>; 77% female) with radiographically diagnosed knee OA (Kellgren-Lawrence [KLG]: 2-4) and moderate to severe pain score (≥6) from the Western Ontario and McMasters Un ...[more]

PMID: 36474875

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Project description:AimsPatients with left ventricular assist device (LVAD) suffer from persistent exercise limitation despite improvement of their heart failure syndrome. Exercise training (ET) programmes to improve aerobic capacity have shown modest efficacy. High-intensity interval training (HIIT), as an alternative to moderate continuous training, has not been systematically tested in this population. We examine the feasibility of a short, personalized HIIT programme in patients with LVAD and describe its effects on aerobic capacity and left ventricular remodelling.Methods and resultsPatients on durable LVAD support were prospectively enrolled in a 15-session, 5 week HIIT programme. Turndown echocardiogram, Kansas City Cardiomyopathy Questionnaire, and cardiopulmonary exercise test were performed before and after HIIT. Training workloads for each subject were based on pretraining peak cardiopulmonary exercise test work rate (W). Percentage of prescribed training workload completed and adverse events were recorded for each subject. Fifteen subjects were enrolled [10 men, age = 51 (29-71) years, HeartMate II = 12, HeartMate 3 = 3, and time on LVAD = 18 (3-64) months]. Twelve completed post-training testing. HIIT was well tolerated, and 90% (inter-quartile range: 78, 99%) of the prescribed workload (W) was completed with no major adverse events. Improvements were seen in aV?O2 at ventilatory threshold [7.1 (6.5, 9.1) to 8.5 (7.7, 9.3) mL/kg/min, P = 0.04], work rate at ventilatory threshold [44 (14, 54) to 55 (21, 66) W, P = 0.05], and left ventricular end-diastolic volume [168 (144, 216) to 159 (124, 212) mL, n = 7, P = 0.02]. HIIT had no effect on maximal oxygen consumption (V?O2peak ) or Kansas City Cardiomyopathy Questionnaire score.ConclusionsCardiopulmonary exercise test-guided HIIT is feasible and can improve submaximal aerobic capacity in stable patients with chronic LVAD support. Further studies are needed on its effects on the myocardium and its potential role in cardiac rehabilitation programmes.

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Dataset Information

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Objective

Design

Results

Conclusions

Trial registration number

Publications

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

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