Ontology highlight
ABSTRACT:
SUBMITTER: Trabjerg MS
PROVIDER: S-EPMC9867753 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Trabjerg Michael Sloth MS Andersen Dennis Christian DC Huntjens Pam P Mørk Kasper K Warming Nikolaj N Kullab Ulla Bismark UB Skjønnemand Marie-Louise Nibelius MN Oklinski Michal Krystian MK Oklinski Kirsten Egelund KE Bolther Luise L Kroese Lona J LJ Pritchard Colin E J CEJ Huijbers Ivo J IJ Corthals Angelique A Søndergaard Mads Toft MT Kjeldal Henrik Bech HB Pedersen Cecilie Fjord Morre CFM Nieland John Dirk Vestergaard JDV
NPJ Parkinson's disease 20230121 1
Glucose metabolism is dysregulated in Parkinson's disease (PD) causing a shift toward the metabolism of lipids. Carnitine palmitoyl-transferase 1A (CPT1A) regulates the key step in the metabolism of long-chain fatty acids. The aim of this study is to evaluate the effect of downregulating CPT1, either genetically with a Cpt1a P479L mutation or medicinally on PD using chronic rotenone mouse models using C57Bl/6J and Park2 knockout mice. We show that Cpt1a P479L mutant mice are resistant to rotenon ...[more]