Ontology highlight
ABSTRACT:
SUBMITTER: Zhu P
PROVIDER: S-EPMC9908015 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Zhu Pancheng P Papadimitriou Vasileios A VA van Dongen Jeanne E JE Cordeiro Julia J Neeleman Yannick Y Santoso Albert A Chen Shuyi S Eijkel Jan C T JCT Peng Hanmin H Segerink Loes I LI Rwei Alina Y AY
Science advances 20230208 6
Endotoxin is a deadly pyrogen, rendering it crucial to monitor with high accuracy and efficiency. However, current endotoxin detection relies on multistep processes that are labor-intensive, time-consuming, and unsustainable. Here, we report an aptamer-based biosensor for the real-time optical detection of endotoxin. The endotoxin sensor exploits the distance-dependent scattering of gold nanoparticles (AuNPs) coupled to a gold nanofilm. This is enabled by the conformational changes of an endotox ...[more]