Ontology highlight
ABSTRACT:
SUBMITTER: Oelschlager L
PROVIDER: S-EPMC9913075 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Oelschläger Lisa L Stahl Paul P Kaschani Farnusch F Stauber Roland H RH Knauer Shirley K SK Hensel Astrid A
Cells 20230118 3
The human protease Taspase1 plays a pivotal role in developmental processes and cancerous diseases by processing critical regulators, such as the leukemia proto-oncoprotein MLL. Despite almost two decades of intense research, Taspase1's biology is, however, still poorly understood, and so far its cellular function was not assigned to a superordinate biological pathway or a specific signaling cascade. Our data, gained by methods such as co-immunoprecipitation, LC-MS/MS and Topoisomerase II DNA cl ...[more]