Ontology highlight
ABSTRACT:
SUBMITTER: Spanov B
PROVIDER: S-EPMC9979147 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Spanov Baubek B Olaleye Oladapo O Mesurado Tomés T Govorukhina Natalia N Jungbauer Alois A van de Merbel Nico C NC Lingg Nico N Bischoff Rainer R
Analytical chemistry 20230216 8
Pertuzumab is a monoclonal antibody used for the treatment of HER2-positive breast cancer in combination with trastuzumab. Charge variants of trastuzumab have been extensively described in the literature; however, little is known about the charge heterogeneity of pertuzumab. Here, changes in the ion-exchange profile of pertuzumab were evaluated by pH gradient cation-exchange chromatography after stressing it for up to 3 weeks at physiological and elevated pH and 37 °C. Isolated charge variants a ...[more]