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Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides.

ABSTRACT: We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates.

SUBMITTER: Song F

PROVIDER: S-EPMC9990065 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Iron-Catalyzed Oxidative α-Amination of Ketones with Primary and Secondary Sulfonamides.

Song Fubin F Park So Hyun SH Wu Christine C Strom Alexandra E AE

The Journal of organic chemistry 20230222 5

We report the iron-catalyzed α-amination of ketones with sulfonamides. Using an oxidative coupling approach, ketones can be directly coupled with free sulfonamides, without the need for prefunctionalization of either substrate. Primary and secondary sulfonamides are both competent coupling partners, with yields from 55% to 88% for deoxybenzoin-derived substrates. ...[more]

PMID: 36811395

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