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Designer nanoscale DNA assemblies programmed from the top down


ABSTRACT:

SUBMITTER: Kaiming Zhang 

PROVIDER: EMPIAR-10068 | biostudies-other |

REPOSITORIES: biostudies-other

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Designer nanoscale DNA assemblies programmed from the top down.

Veneziano Rémi R   Ratanalert Sakul S   Zhang Kaiming K   Zhang Fei F   Yan Hao H   Chiu Wah W   Bathe Mark M  

Science (New York, N.Y.) 20160526 6293


Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick base pairing manually for any given target structure. Here, we report a general, top-down strategy to design nearly arbitrary DNA architectures autonomously based only on target shape. Objects are represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes, which enables complete DNA scaffold  ...[more]

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