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'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach.

ABSTRACT: We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.

SUBMITTER: Hu CM

PROVIDER: S-EPMC3667603 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach.

Hu Che-Ming J CM Fang Ronnie H RH Luk Brian T BT Chen Kevin N H KN Carpenter Cody C Gao Weiwei W Zhang Kang K Zhang Liangfang L

Nanoscale 20130401 7

We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs. ...[more]

PMID: 23462967

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