Ontology highlight
ABSTRACT:
SUBMITTER: Thi Hoang Duong Nguyen
PROVIDER: EMPIAR-10073 | biostudies-other |
REPOSITORIES: biostudies-other
Nguyen Thi Hoang Duong THD Galej Wojciech P WP Bai Xiao-Chen XC Oubridge Chris C Newman Andrew J AJ Scheres Sjors H W SHW Nagai Kiyoshi K
Nature 20160201 7590
U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of Saccharomyces cerevisiae U4/U6.U5 tri-snRNP at 3.7 Å resolution led to an essentially complete atomic model comprising 30 proteins plus U4/U6 and U5 small nuclear RNAs (snRNAs). The structure reveals striking interweaving interactions of the protein and RNA components, including extended polypeptides penetrating into subunit interfaces. The invariant ACAGAGA sequence of ...[more]