A "drug sweeping" state of the TriABC triclosan efflux pump from Pseudomonas aeruginosa
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ABSTRACT:
SUBMITTER: Isabelle Rouiller
PROVIDER: EMPIAR-10128 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.
Fabre Lucien L Ntreh Abigail T AT Yazidi Amira A Leus Inga V IV Weeks Jon W JW Bhattacharyya Sudipta S Ruickoldt Jakob J Rouiller Isabelle I Zgurskaya Helen I HI Sygusch Jurgen J
Structure (London, England : 1993) 20200922 3
The structure of the TriABC inner membrane component of the triclosan/SDS-specific efflux pump from Pseudomonas aeruginosa was determined by cryoelectron microscopy to 4.5 Å resolution. The complete structure of the inner membrane transporter TriC of the resistance-nodulation-division (RND) superfamily was solved, including a partial structure of the fused periplasmic membrane fusion subunits, TriA and TriB. The substrate-free conformation of TriABC represents an intermediate step in efflux comp ...[more]
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