Conformational Dynamics of human Bact spliceosome
Ontology highlight
ABSTRACT:
SUBMITTER: David Haselbach
PROVIDER: EMPIAR-10160 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure and Conformational Dynamics of the Human Spliceosomal B<sup>act</sup> Complex.
Haselbach David D Komarov Ilya I Agafonov Dmitry E DE Hartmuth Klaus K Graf Benjamin B Dybkov Olexandr O Urlaub Henning H Kastner Berthold B Lührmann Reinhard R Stark Holger H
Cell 20180117 3
The spliceosome is a highly dynamic macromolecular complex that precisely excises introns from pre-mRNA. Here we report the cryo-EM 3D structure of the human B<sup>act</sup> spliceosome at 3.4 Å resolution. In the B<sup>act</sup> state, the spliceosome is activated but not catalytically primed, so that it is functionally blocked prior to the first catalytic step of splicing. The spliceosomal core is similar to the yeast B<sup>act</sup> spliceosome; important differences include the presence of t ...[more]
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