An atomic structure of human gamma-secretase
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ABSTRACT:
SUBMITTER: Sjors Scheres
PROVIDER: EMPIAR-10194 | biostudies-other |
REPOSITORIES: biostudies-other
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An atomic structure of human γ-secretase.
Bai Xiao-Chen XC Yan Chuangye C Yang Guanghui G Lu Peilong P Ma Dan D Sun Linfeng L Zhou Rui R Scheres Sjors H W SHW Shi Yigong Y
Nature 20150817 7568
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-electron microscopy. Mutations derived from Alzheimer's disease affect residues at two hotspots in PS1, each located at the centre of a distinct four transmembrane segment (TM) bundle. TM ...[more]
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