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An atomic structure of human gamma-secretase


ABSTRACT:

SUBMITTER: Sjors Scheres 

PROVIDER: EMPIAR-10194 | biostudies-other |

REPOSITORIES: biostudies-other

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Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-electron microscopy. Mutations derived from Alzheimer's disease affect residues at two hotspots in PS1, each located at the centre of a distinct four transmembrane segment (TM) bundle. TM  ...[more]

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