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Single particle cryoEM of mouse protocadherin gamma B6

ABSTRACT:

SUBMITTER: Lawrence Shapiro

PROVIDER: EMPIAR-10234 | biostudies-other |

REPOSITORIES: biostudies-other

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Visualization of clustered protocadherin neuronal self-recognition complexes.

Brasch Julia J Goodman Kerry M KM Noble Alex J AJ Rapp Micah M Mannepalli Seetha S Bahna Fabiana F Dandey Venkata P VP Bepler Tristan T Berger Bonnie B Maniatis Tom T Potter Clinton S CS Carragher Bridget B Honig Barry B Shapiro Lawrence L

Nature 20190410 7755

Neurite self-recognition and avoidance are fundamental properties of all nervous systems1. These processes facilitate dendritic arborization2,3, prevent formation of autapses4 and allow free interaction among non-self neurons1,2,4,5. Avoidance among self neurites is mediated by stochastic cell-surface expression of combinations of about 60 isoforms of α-, β- and γ-clustered protocadherin that provide mammalian neurons with single-cell identities1, ...[more]

PMID: 30971825

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