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3.2 Å Single-Particle Cryo-EM Reconstruction of 49 kDa Membrane-Bound PfCRT Complexed with Fab

ABSTRACT:

SUBMITTER: Yong Zi Tan

PROVIDER: EMPIAR-10330 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.

Kim Jonathan J Tan Yong Zi YZ Wicht Kathryn J KJ Erramilli Satchal K SK Dhingra Satish K SK Okombo John J Vendome Jeremie J Hagenah Laura M LM Giacometti Sabrina I SI Warren Audrey L AL Nosol Kamil K Roepe Paul D PD Potter Clinton S CS Carragher Bridget B Kossiakoff Anthony A AA Quick Matthias M Fidock David A DA Mancia Filippo F

Nature 20191127 7786

The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide<sup>1</sup>. Clinical resistance to the chemically related current first-line combination drug piperaquine (P ...[more]

PMID: 31776516

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