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Helical Reconstruction of a left-handed and membrnae-bound ESCRT-III copolymer comprised of human CHMP1B and IST1

ABSTRACT:

SUBMITTER: Adam Frost

PROVIDER: EMPIAR-10395 | biostudies-other |

REPOSITORIES: biostudies-other

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Membrane constriction and thinning by sequential ESCRT-III polymerization.

Nguyen Henry C HC Talledge Nathaniel N McCullough John J Sharma Abhimanyu A Moss Frank R FR Iwasa Janet H JH Vershinin Michael D MD Sundquist Wesley I WI Frost Adam A

Nature structural & molecular biology 20200406 4

The endosomal sorting complexes required for transport (ESCRTs) mediate diverse membrane remodeling events. These typically require ESCRT-III proteins to stabilize negatively curved membranes; however, recent work has indicated that certain ESCRT-IIIs also participate in positive-curvature membrane-shaping reactions. ESCRT-IIIs polymerize into membrane-binding filaments, but the structural basis for negative versus positive membrane remodeling by these proteins remains poorly understood. To lear ...[more]

PMID: 32251413

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