Structure of human GABA(B) receptor in an inactive state
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ABSTRACT:
SUBMITTER: Qing Rong Fan
PROVIDER: EMPIAR-10410 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of human GABA<sub>B</sub> receptor in an inactive state.
Park Jinseo J Fu Ziao Z Frangaj Aurel A Liu Jonathan J Mosyak Lidia L Shen Tong T Slavkovich Vesna N VN Ray Kimberly M KM Taura Jaume J Cao Baohua B Geng Yong Y Zuo Hao H Kou Yongjun Y Grassucci Robert R Chen Shaoxia S Liu Zheng Z Lin Xin X Williams Justin P JP Rice William J WJ Eng Edward T ET Huang Rick K RK Soni Rajesh K RK Kloss Brian B Yu Zhiheng Z Javitch Jonathan A JA Hendrickson Wayne A WA Slesinger Paul A PA Quick Matthias M Graziano Joseph J Yu Hongtao H Fiehn Oliver O Clarke Oliver B OB Frank Joachim J Fan Qing R QR
Nature 20200624 7820
The human GABA<sub>B</sub> receptor-a member of the class C family of G-protein-coupled receptors (GPCRs)-mediates inhibitory neurotransmission and has been implicated in epilepsy, pain and addiction<sup>1</sup>. A unique GPCR that is known to require heterodimerization for function<sup>2-6</sup>, the GABA<sub>B</sub> receptor has two subunits, GABA<sub>B1</sub> and GABA<sub>B2</sub>, that are structurally homologous but perform distinct and complementary functions. GABA<sub>B1</sub> recognizes ...[more]
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