Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation
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ABSTRACT:
SUBMITTER: Rajendra K Agrawal
PROVIDER: EMPIAR-10481 | biostudies-other |
REPOSITORIES: biostudies-other
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Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
Koripella Ravi Kiran RK Sharma Manjuli R MR Bhargava Kalpana K Datta Partha P PP Kaushal Prem S PS Keshavan Pooja P Spremulli Linda L LL Banavali Nilesh K NK Agrawal Rajendra K RK
Nature communications 20200731 1
The mammalian mitochondrial ribosome (mitoribosome) and its associated translational factors have evolved to accommodate greater participation of proteins in mitochondrial translation. Here we present the 2.68-3.96 Å cryo-EM structures of the human 55S mitoribosome in complex with the human mitochondrial elongation factor G1 (EF-G1<sub>mt</sub>) in three distinct conformational states, including an intermediate state and a post-translocational state. These structures reveal the role of several m ...[more]
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