Movies of Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
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ABSTRACT:
SUBMITTER: Christopher J Russo
PROVIDER: EMPIAR-10517 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
Naydenova Katerina K Muir Kyle W KW Wu Long-Fei LF Zhang Ziguo Z Coscia Francesca F Peet Mathew J MJ Castro-Hartmann Pablo P Qian Pu P Sader Kasim K Dent Kyle K Kimanius Dari D Sutherland John D JD Löwe Jan J Barford David D Russo Christopher J CJ
Proceedings of the National Academy of Sciences of the United States of America 20210201 7
The RNA polymerase inhibitor favipiravir is currently in clinical trials as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite limited information about the molecular basis for its activity. Here we report the structure of favipiravir ribonucleoside triphosphate (favipiravir-RTP) in complex with the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) bound to a template:primer RNA duplex, determined by electron cryomicroscopy (cryoEM) to a resolution ...[more]
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