Ontology highlight
ABSTRACT:
SUBMITTER: Shannon A
PROVIDER: S-EPMC7263509 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20200515
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. Here we show that Favipiravir exerts an antiviral effect as a nucleotide analogue through a combination of chain termination, slowed RNA synthesis and l ...[more]