Dataset Information
Unaligned movies for FANCD2-FANCI + DNA
Ontology highlight
ABSTRACT:
SUBMITTER: Lori A Passmore
PROVIDER: EMPIAR-10609 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
Nature structural & molecular biology 20200217 3
Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair is monoubiquitination of the FANCD2-FANCI heterodimer, which then recruits nucleases to remove the DNA lesion. Here, we use cryo-EM to determine the structures of recombinant chicken FANCD2 and FANCI complexes. FANCD2-FANCI adopts a closed conforma ...[more]