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Unaligned movies for ubFANCD2-FANCI + DNA

ABSTRACT:

SUBMITTER: Lori A Passmore 

PROVIDER: EMPIAR-10611 | biostudies-other |

REPOSITORIES: biostudies-other

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FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Alcón Pablo P   Shakeel Shabih S   Chen Zhuo A ZA   Rappsilber Juri J   Patel Ketan J KJ   Passmore Lori A LA  

Nature structural & molecular biology 20200217 3

Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks. Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause Fanconi anemia (FA). A key step in crosslink repair is monoubiquitination of the FANCD2-FANCI heterodimer, which then recruits nucleases to remove the DNA lesion. Here, we use cryo-EM to determine the structures of recombinant chicken FANCD2 and FANCI complexes. FANCD2-FANCI adopts a closed conforma  ...[more]

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