Dataset Information
Alpha-E-catenin ABD-F-actin complex
Ontology highlight
ABSTRACT:
SUBMITTER: Gregory Matthew Alushin
PROVIDER: EMPIAR-10654 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism for direct actin force-sensing by α-catenin.
eLife 20200924
The actin cytoskeleton mediates mechanical coupling between cells and their tissue microenvironments. The architecture and composition of actin networks are modulated by force; however, it is unclear how interactions between actin filaments (F-actin) and associated proteins are mechanically regulated. Here we employ both optical trapping and biochemical reconstitution with myosin motor proteins to show single piconewton forces applied solely to F-actin enhance binding by the human version of the ...[more]