Metavinculin ABD-F-actin complex
Ontology highlight
ABSTRACT:
SUBMITTER: Gregory Matthew Alushin
PROVIDER: EMPIAR-10663 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism for direct actin force-sensing by α-catenin.
Mei Lin L Espinosa de Los Reyes Santiago S Reynolds Matthew J MJ Leicher Rachel R Liu Shixin S Alushin Gregory M GM
eLife 20200924
The actin cytoskeleton mediates mechanical coupling between cells and their tissue microenvironments. The architecture and composition of actin networks are modulated by force; however, it is unclear how interactions between actin filaments (F-actin) and associated proteins are mechanically regulated. Here we employ both optical trapping and biochemical reconstitution with myosin motor proteins to show single piconewton forces applied solely to F-actin enhance binding by the human version of the ...[more]
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