Subtomograms of nucleosomes extracted from cryo-tomograms of Drosophila melanogaster embryos
Ontology highlight
ABSTRACT:
SUBMITTER: Mikhail Eltsov
PROVIDER: EMPIAR-10679 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
HEMNMA-3D: Cryo Electron Tomography Method Based on Normal Mode Analysis to Study Continuous Conformational Variability of Macromolecular Complexes.
Harastani Mohamad M Eltsov Mikhail M Leforestier Amélie A Jonic Slavica S
Frontiers in molecular biosciences 20210519
Cryogenic electron tomography (cryo-ET) allows structural determination of biomolecules in their native environment (<i>in situ</i>). Its potential of providing information on the dynamics of macromolecular complexes in cells is still largely unexploited, due to the challenges of the data analysis. The crowded cell environment and continuous conformational changes of complexes make difficult disentangling the data heterogeneity. We present HEMNMA-3D, which is, to the best of our knowledge, the f ...[more]
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