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Cryo electron microscopy final particle stacks of Substance P-Neurokinin Receptor G protein complexes

ABSTRACT:

SUBMITTER: Aashish Manglik

PROVIDER: EMPIAR-10786 | biostudies-other |

REPOSITORIES: biostudies-other

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Selective G protein signaling driven by substance P-neurokinin receptor dynamics.

Harris Julian A JA Faust Bryan B Gondin Arisbel B AB Dämgen Marc André MA Suomivuori Carl-Mikael CM Veldhuis Nicholas A NA Cheng Yifan Y Dror Ron O RO Thal David M DM Manglik Aashish A

Nature chemical biology 20211028 1

The neuropeptide substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via Gq and Gs proteins. Neurokinin A also activates NK1R, but leads to selective Gq signaling. How two stimuli yield distinct G protein signaling at the same G protein-coupled receptor remains unclear. We determined cryogenic-electron microscopy structures of active NK1R bound to SP or the Gq-biased peptide SP6-11. Peptide in ...[more]

PMID: 34711980

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