Single particle cryo-EM of red blood cell lysate (hemolysate, hemoglobin reduced, filtered by SEC)
Ontology highlight
ABSTRACT:
SUBMITTER: Edward M. Marcotte
PROVIDER: EMPIAR-10848 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The protein organization of a red blood cell.
Sae-Lee Wisath W McCafferty Caitlyn L CL Verbeke Eric J EJ Havugimana Pierre C PC Papoulas Ophelia O McWhite Claire D CD Houser John R JR Vanuytsel Kim K Murphy George J GJ Drew Kevin K Emili Andrew A Taylor David W DW Marcotte Edward M EM
Cell reports 20220701 3
Red blood cells (RBCs) (erythrocytes) are the simplest primary human cells, lacking nuclei and major organelles and instead employing about a thousand proteins to dynamically control cellular function and morphology in response to physiological cues. In this study, we define a canonical RBC proteome and interactome using quantitative mass spectrometry and machine learning. Our data reveal an RBC interactome dominated by protein homeostasis, redox biology, cytoskeletal dynamics, and carbon metabo ...[more]
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