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CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14


ABSTRACT:

SUBMITTER: Jonathan Firoze Fay 

PROVIDER: EMPIAR-10853 | biostudies-other |

REPOSITORIES: biostudies-other

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The MRGPRX family of receptors (MRGPRX1-4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently<sup>1</sup>. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions<sup>2-5</sup>. MRGPRX2 couples to both G<sub>i</sub> and G<sub>q</sub> in mast cells<sup>6</sup>. Here we describe agonist-stabilized structures of MRGPRX2 coupled to G<sub>i1</sub> and G<sub>q</sub> in ter  ...[more]

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