Dataset Information
CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-10853 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure, function and pharmacology of human itch GPCRs.
Nature 20211117 7887
The MRGPRX family of receptors (MRGPRX1-4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently<sup>1</sup>. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions<sup>2-5</sup>. MRGPRX2 couples to both G<sub>i</sub> and G<sub>q</sub> in mast cells<sup>6</sup>. Here we describe agonist-stabilized structures of MRGPRX2 coupled to G<sub>i1</sub> and G<sub>q</sub> in ter ...[more]