Dataset Information
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 & ML382
Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-11188 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.
Nature chemical biology 20221027 4
The human MAS-related G protein-coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved in the mediation of nociception and pruritus. Central activation of MRGPRX1 by the endogenous opioid peptide fragment BAM8-22 and its positive allosteric modulator ML382 has been shown to effectively inhibit persistent pain, making MRGPRX1 a promising target for non-opioid pain treatment. However, the activation mechanism of MRGPRX1 is still largely ...[more]