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Single particle cryogenic electron micrographs of tetrahymena mitochondrial electron transport chain complexes

ABSTRACT:

SUBMITTER: James Anthony Letts

PROVIDER: EMPIAR-10919 | biostudies-other |

REPOSITORIES: biostudies-other

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Structures of Tetrahymena's respiratory chain reveal the diversity of eukaryotic core metabolism.

Zhou Long L Maldonado María M Padavannil Abhilash A Guo Fei F Letts James A JA

Science (New York, N.Y.) 20220331 6595

Respiration is a core biological energy-converting process whose last steps are carried out by a chain of multisubunit complexes in the inner mitochondrial membrane. To probe the functional and structural diversity of eukaryotic respiration, we examined the respiratory chain of the ciliate Tetrahymena thermophila (Tt). Using cryo-electron microscopy on a mixed sample, we solved structures of a supercomplex between Tt complex I (Tt-CI) and Tt-CIII2 (Tt-SC I+III2) and ...[more]

PMID: 35357889

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