Cryo electron microscopy SMARCAD1 with nucleosome in ADP-BeF3 bound state
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ABSTRACT:
SUBMITTER: Karolin Luger
PROVIDER: EMPIAR-10939 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity.
Markert Jonathan J Zhou Keda K Luger Karolin K
Science advances 20211015 42
The adenosine 5′-triphosphate (ATP)–dependent chromatin remodeler SMARCAD1 acts on nucleosomes during DNA replication, repair, and transcription, but despite its implication in disease, information on its function and biochemical activities is scarce. Chromatin remodelers use the energy of ATP hydrolysis to slide nucleosomes, evict histones, or exchange histone variants. Here, we show that SMARCAD1 transfers the entire histone octamer from one DNA segment to another in an ATP-dependent manner bu ...[more]
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