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Cryo-EM reconstruction of TMEM106B fold I-d filaments from case 18 with multiple system atrophy

ABSTRACT:

SUBMITTER: Manuel Schweighauser

PROVIDER: EMPIAR-10968 | biostudies-other |

REPOSITORIES: biostudies-other

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Age-dependent formation of TMEM106B amyloid filaments in human brains.

Schweighauser Manuel M Arseni Diana D Bacioglu Mehtap M Huang Melissa M Lövestam Sofia S Shi Yang Y Yang Yang Y Zhang Wenjuan W Kotecha Abhay A Garringer Holly J HJ Vidal Ruben R Hallinan Grace I GI Newell Kathy L KL Tarutani Airi A Murayama Shigeo S Miyazaki Masayuki M Saito Yuko Y Yoshida Mari M Hasegawa Kazuko K Lashley Tammaryn T Revesz Tamas T Kovacs Gabor G GG van Swieten John J Takao Masaki M Hasegawa Masato M Ghetti Bernardino B Spillantini Maria Grazia MG Ryskeldi-Falcon Benjamin B Murzin Alexey G AG Goedert Michel M Scheres Sjors H W SHW

Nature 20220328 7909

Many age-dependent neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and transactive response DNA-binding protein (TARDBP; also known as TDP-43) are the most common<sup>1,2</sup>. Here we used structure determination by cryogenic electron microscopy to show that residues 120-254 of the lysosomal type II transmembrane protein 106B (TMEM106B) also form am ...[more]

PMID: 35344985

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