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Cryo electron-microscopy of TMEM106B fibrils extracted from four FTLD-TDP patient brains

ABSTRACT:

SUBMITTER: Yi Xiao Jiang

PROVIDER: EMPIAR-11041 | biostudies-other |

REPOSITORIES: biostudies-other

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Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.

Jiang Yi Xiao YX Cao Qin Q Sawaya Michael R MR Abskharon Romany R Ge Peng P DeTure Michael M Dickson Dennis W DW Fu Janine Y JY Ogorzalek Loo Rachel R RR Loo Joseph A JA Loo Joseph A JA Eisenberg David S DS

Nature 20220328 7909

Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer's and Parkinson's diseases1. FTLD typically presents in 45 to 64 year olds with behavioural changes or progressive decline of language skills2. The subtype FTLD-TDP is characterized by certain clinical symptoms and pathological neuronal inclusions with TAR DNA-binding protein (TDP-43) immunoreactivity3. Here we extracted amyloid fibrils from brains of fou ...[more]

PMID: 35344984

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