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CryoEM single particle dataset for psNb 1-8 with spike protein


ABSTRACT:

SUBMITTER: Wei Huang 

PROVIDER: EMPIAR-11102 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications


Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies with improved potency and breadth. Here, we observe superimmunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain (RBD). We rapidly isolate a large repertoire of specific ultra-high-affinity nanobodies that bind strongly to all known sarbecovirus clades using integrative proteomics. These pan-sarbecovirus nanobodies (psNbs) are highly effective against SARS-CoV and SARS-CoV-2 var  ...[more]

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