Dataset Information
CryoEM single particle dataset for psNb 1-22 with spike protein
Ontology highlight
ABSTRACT:
SUBMITTER: Wei Huang
PROVIDER: EMPIAR-11105 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Superimmunity by pan-sarbecovirus nanobodies.
Cell reports 20220608 13
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies with improved potency and breadth. Here, we observe superimmunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain (RBD). We rapidly isolate a large repertoire of specific ultra-high-affinity nanobodies that bind strongly to all known sarbecovirus clades using integrative proteomics. These pan-sarbecovirus nanobodies (psNbs) are highly effective against SARS-CoV and SARS-CoV-2 var ...[more]