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CryoEM single particle dataset of alpha-latrocrustotoxin monomer


ABSTRACT:

SUBMITTER: Minghao Chen 

PROVIDER: EMPIAR-10827 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Molecular architecture of black widow spider neurotoxins.

Chen Minghao M   Blum Daniel D   Engelhard Lena L   Raunser Stefan S   Wagner Richard R   Gatsogiannis Christos C  

Nature communications 20211129 1


Latrotoxins (LaTXs) are presynaptic pore-forming neurotoxins found in the venom of Latrodectus spiders. The venom contains a toxic cocktail of seven LaTXs, with one of them targeting vertebrates (α-latrotoxin (α-LTX)), five specialized on insects (α, β, γ, δ, ε- latroinsectotoxins (LITs), and one on crustaceans (α-latrocrustatoxin (α-LCT)). LaTXs bind to specific receptors on the surface of neuronal cells, inducing the release of neurotransmitters either by directly stimulating exocytosis or by  ...[more]

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