Micrographs of Rigid-Rod Aromatics pBP-NBD
Ontology highlight
ABSTRACT:
SUBMITTER: Fengbin Wang
PROVIDER: EMPIAR-11259 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Enzyme Responsive Rigid-Rod Aromatics Target "Undruggable" Phosphatases to Kill Cancer Cells in a Mimetic Bone Microenvironment.
Yi Meihui M Wang Fengbin F Tan Weiyi W Hsieh Jer-Tsong JT Egelman Edward H EH Xu Bing B
Journal of the American Chemical Society 20220718 29
Bone metastasis remains a challenge in cancer treatment. Here we show enzymatic responsive rigid-rod aromatics acting as the substrates of "undruggable" phosphatases to kill cancer cells in a mimetic bone microenvironment. By phosphorylation and conjugating nitrobenzoxadiazole (NBD) to hydroxybiphenylcarboxylate (BP), we obtained pBP-NBD (<b>1P</b>) as a substrate of both acid and alkaline phosphatases. <b>1P</b> effectively kills both metastatic castration-resistant prostate cancer cells (mCRPC ...[more]
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