Dataset Information
Single particle cryo-EM dataset of Yarrowia lipolytica mitochondrial complex I with R121M NDUFS2/NUCM mutation
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-11663 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I.
The Journal of biological chemistry 20210101
Respiratory complex I (NADH:ubiquinone oxidoreductase), the first enzyme of the electron-transport chain, captures the free energy released by NADH oxidation and ubiquinone reduction to translocate protons across an energy-transducing membrane and drive ATP synthesis during oxidative phosphorylation. The cofactor that transfers the electrons directly to ubiquinone is an iron-sulfur cluster (N2) located in the NDUFS2/NUCM subunit. A nearby arginine residue (R121), which forms part of the second c ...[more]