Ontology highlight
ABSTRACT:
SUBMITTER: Luciano Graciani Dolce
PROVIDER: EMPIAR-11673 | biostudies-other |
REPOSITORIES: biostudies-other
Dolce Luciano G LG Zimmer Aubree A AA Tengo Laura L Weis Félix F Rubio Mary Anne T MAT Alfonzo Juan D JD Kowalinski Eva E
Nature communications 20221108 1
The essential deamination of adenosine A<sub>34</sub> to inosine at the wobble base is the individual tRNA modification with the greatest effects on mRNA decoding, empowering a single tRNA to translate three different codons. To date, many aspects of how eukaryotic deaminases specifically select their multiple substrates remain unclear. Here, using cryo-EM, we present the structure of a eukaryotic ADAT2/3 deaminase bound to a full-length tRNA, revealing that the enzyme distorts the anticodon loo ...[more]