The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome
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ABSTRACT:
SUBMITTER: Tinghai Xu
PROVIDER: EMPIAR-11732 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.
Xu Ting-Hai TH Liu Minmin M Zhou X Edward XE Liang Gangning G Zhao Gongpu G Xu H Eric HE Melcher Karsten K Jones Peter A PA
Nature 20200923 7827
CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer<sup>1</sup>. These two DNMTs preferentially bind to nucleosomes, yet cannot methylate the DNA wrapped around the nucleosome core<sup>2</sup>, and they favour the methylation of linker DNA at positioned nucleosomes<sup>3,4</sup>. Here we present the cryo-electron microscopy structure of a ternary complex of catalytically competent ...[more]
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