Dataset Information
The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome
Ontology highlight
ABSTRACT:
SUBMITTER: Tinghai Xu
PROVIDER: EMPIAR-11732 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.
Nature 20200923 7827
CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer<sup>1</sup>. These two DNMTs preferentially bind to nucleosomes, yet cannot methylate the DNA wrapped around the nucleosome core<sup>2</sup>, and they favour the methylation of linker DNA at positioned nucleosomes<sup>3,4</sup>. Here we present the cryo-electron microscopy structure of a ternary complex of catalytically competent ...[more]
