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CryoEM movies of human tau amyloid fibrils extracted from an AD patient brain (in association with in situ cryoET)

ABSTRACT:

SUBMITTER: René AW Frank

PROVIDER: EMPIAR-12045 | biostudies-other |

REPOSITORIES: biostudies-other

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CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain.

Gilbert Madeleine A G MAG Fatima Nayab N Jenkins Joshua J O'Sullivan Thomas J TJ Schertel Andreas A Halfon Yehuda Y Wilkinson Martin M Morrema Tjado H J THJ Geibel Mirjam M Read Randy J RJ Ranson Neil A NA Radford Sheena E SE Hoozemans Jeroen J M JJM Frank René A W RAW

Nature 20240710 8022

A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures<sup>1</sup>. In Alzheimer's disease, this is characterized by the deposition of β-amyloid and tau with disease-specific conformations. The in situ structure of amyloid in the human brain is unknown. Here, using cryo-fluorescence microscopy-targeted cryo-sectioning, cryo-focused ion beam-scanning electron microscopy lift-out and cryo-electron tomography ...[more]

PMID: 38987603

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