Dataset Information
Tomograms and the raw 2d tilt series of ER-nuclear envelope junctions of HeLa cells in early telophase
Ontology highlight
ABSTRACT:
SUBMITTER: Shotaro Otsuka
PROVIDER: EMPIAR-12048 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after mitosis.
EMBO reports 20240614 7
Junctions between the endoplasmic reticulum (ER) and the outer membrane of the nuclear envelope (NE) physically connect both organelles. These ER-NE junctions are essential for supplying the NE with lipids and proteins synthesized in the ER. However, little is known about the structure of these ER-NE junctions. Here, we systematically study the ultrastructure of ER-NE junctions in cryo-fixed mammalian cells staged in anaphase, telophase, and interphase by correlating live cell imaging with three ...[more]