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Identification of mRNAs modulated by overexpression of N-terminal G3BP

ABSTRACT: Transcripts upregulated or downregulated by overexpression of N-terminal G3BP were identified through expression profiling of a total of 12,135 genes in comparison with S2-013 clones in which N-terminal G3BP is overexpressed and control clones. We endeavored to identify factors and pathways regulated by CD24 and to obtain leads regarding the mechanism underpinning the observed phenotypic changes by performing cDNA microarray analysis on two S2-013 CD24 RNAi clones and two control clones. Total RNAs from two clones of S2-013 CD24 RNAi or control cells were mixed and used for cDNA microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Taniuchi Keisuke

PROVIDER: S-ECPF-GEOD-23342 | biostudies-other |

REPOSITORIES: biostudies-other

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Identification of mRNAs modulated by overexpression of N-terminal G3BP

Project description:Transcripts upregulated or downregulated by overexpression of N-terminal G3BP were identified through expression profiling of a total of 12,135 genes in comparison with S2-013 clones in which N-terminal G3BP is overexpressed and control clones. We endeavored to identify factors and pathways regulated by CD24 and to obtain leads regarding the mechanism underpinning the observed phenotypic changes by performing cDNA microarray analysis on two S2-013 CD24 RNAi clones and two control clones. Total RNAs from two clones of S2-013 CD24 RNAi or control cells were mixed and used for cDNA microarray analysis.

2010-07-31 | E-GEOD-23342 | biostudies-arrayexpress

Identification of mRNAs modulated by overexpression of N-terminal G3BP

2010-07-31 | GSE23342 | GEO

Identification of mRNAs modulated by knockdown of CD24

Project description:We endeavored to identify factors and pathways regulated by CD24 and to obtain leads regarding the mechanism by which CD24 inhibited the invasiveness and metastasis of pancreatic cancer cells by performing cDNA microarray analysis on S2-013 CD24 RNAi clones and control clones. The group of genes showing increased expression was mainly comprised of genes for molecules with functions related to RNA metabolism, transcription factors, proteases, and molecules involved in embryonic development and cell growth. The set of genes downregulated by knockdown of CD24 included the target mRNAs of a phosphorylation-dependent endoribonuclease G3BP that interacted with CD24. The target mRNAs of G3BP were identified in GSE17056. These results suggested that CD24 inhibited the RNase activity of G3BP, and that a function of CD24 was to inhibit the degradation of specific mRNAs. Transcripts upregulated or downregulated by knockdown of CD24 were identified through expression profiling of a total of 12,135 genes in S2-013 CD24 RNAi clones compared to control clones. Before labeling with Cy5 or Cy3, total RNA from two S2-013 CD24 RNAi clones were mixed and total RNA from two control clones were mixed. The supplementary files 'GSE17055_higher_siCD24.txt' and 'GSE17055_higher_control.txt' list the differentially expressed genes.

| S-ECPF-GEOD-17055 | biostudies-other

Identification of mRNAs modulated by knockdown of CD24

2010-06-24 | E-GEOD-17055 | biostudies-arrayexpress

Identification of mRNAs modulated by knockdown of CD24

2009-07-23 | GSE17055 | GEO

Identification of genes modulated by Nurr1 overexpression

Project description:Identification of genes modulated by Nurr1 overexpression in HB-1

2014-08-01 | GSE58475 | GEO

Identification of genes modulated by Nurr1 overexpression

Project description:Identification of genes modulated by Nurr1 overexpression in HB-1 HB-1 cells overexpressing Nurr1

2014-08-01 | E-GEOD-58475 | biostudies-arrayexpress

Identification of mRNAs modulated by the HOXB7-MEK signaling cascade

Project description:Transcripts upregulated or downregulated by HOXB7-MEK signaling were identified for use on the microarray using the Affymetrix GeneChip WT PLUS Reagent Kit in comparison with HOXB7-knockdown S2-013 cells that were transfected with rescue-HOXB7 plasmid and treated with MEK inhibitor, and HOXB7-knockdown S2-013 cells that were transfected with rescue-HOXB7 plasmid but not treated with MEK inhibitor.

2017-09-13 | GSE97969 | GEO

Identification of mRNAs modulated by knockdown of CD24 and enriched in G3BP immunoprecipitation

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-07-23 | GSE17057 | GEO

Identification of differently expressed mRNAs in LNPPS overexpression bladder cancer cells

Project description:In this study, we aimed to explore RNAs profiling regulated by LNPPS in bladder cancer. RNA-seq analysis of three pairs of LNPPS-overexpressing 5637 cells and control cells was completed in this project. A total of 17.6Gb raw data was obtained. In concluion, our data showed that the overexpression of LNPPS caused the significantly upregulation of 82 mRNAs, and the downregulation of 102 mRNAs (|Log2FC|>1.5, p<0.05). Further studies will focus on the potential regulatory mechanisms of these significantly differently expressed mRNAs in the LNPPS-mediated development of bladder cancer.

2023-01-04 | GSE190917 | GEO

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