Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.
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ABSTRACT:
SUBMITTER: Hughes AL
PROVIDER: S-EPMC1088819 | biostudies-other | 2001 Sep
REPOSITORIES: biostudies-other
Publications
Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.
Proceedings. Biological sciences 20010901 1478
It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum-likelihood methods yielded the conclusion that the effective population size of this ...[more]
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