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Intermediate filaments in smooth muscle from pregnant and non-pregnant human uterus.


ABSTRACT: The intermediate filament proteins desmin and vimentin from pregnant and non-pregnant uterine muscle and smooth-muscle cells in culture were analysed using SDS/PAGE. The desmin content in uterine muscle increases dramatically during pregnancy, whereas vimentin remains unchanged or changes very little. When muscle cells are kept in culture, a considerable increase in vimentin content is observed as compared with vimentin in freshly isolated non-pregnant uterine tissue. Our results strengthen the view that vimentin and desmin filaments have independent function and turnover, and point to a predominantly structural role for desmin filaments.

SUBMITTER: Leoni P 

PROVIDER: S-EPMC1131526 | biostudies-other | 1990 Jul

REPOSITORIES: biostudies-other

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