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Collagen fibril formation in the presence of sodium dodecyl sulphate.


ABSTRACT: Sodium dodecyl sulphate (SDS) was used to weaken both the electrostatic and the hydrophobic interactions during collagen fibrillogenesis in vitro. The rate and extent of fibril formation as well as fibril morphology were affected by SDS concentration. Both the formation of large fibrils at 0.3 mM-SDS and the complete cessation of fibril formation at 0.5 mM-SDS were considered to be the result of SDS-induced conformational changes in the non-helical telopeptides. A possible mechanism of SDS interaction with the N-terminal and the distal region of the C-terminal telopeptides is offered.

SUBMITTER: Dombi GW 

PROVIDER: S-EPMC1145022 | biostudies-other | 1985 Jun

REPOSITORIES: biostudies-other

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