Interaction between calmodulin and five different spin-labelled chlorophenothiazines.
Ontology highlight
ABSTRACT: The binding to purified calmodulin of five spin-labelled derivatives of chlorophenothiazine was investigated by e.s.r. spectrometry and by the antagonizing potency on the calmodulin-dependent activation of myosin light chain kinase. The results of a comparative study and the influence of pH and ionic strength on the binding support the occurrence of an electrostatic binding involving the terminal amino group of the side-chain of the chlorophenothiazine. These results are discussed in relation to the specificity of the interaction that holds the antipsychotic drug-calmodulin complex together.
SUBMITTER: Olivier JL
PROVIDER: S-EPMC1153107 | biostudies-other | 1986 Feb
REPOSITORIES: biostudies-other
ACCESS DATA