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Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.


ABSTRACT: In hepatocytes from lean mice vasopressin decreased ketogenesis and increased 14CO2 production from [1-14C]oleate and glucose release; these effects were Ca2+-dependent. None of these effects of vasopressin were obtained with hepatocytes from obese (ob/ob) mice. Similarly, adrenaline did not increase 14CO2 production in these hepatocytes, but it stimulated glucose release. Possible reasons for the impairment of vasopressin action are discussed.

SUBMITTER: Edwards MW 

PROVIDER: S-EPMC1163235 | biostudies-other | 1981 Jul

REPOSITORIES: biostudies-other

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